Inhibitors | Comment | Organism | Structure |
---|---|---|---|
baicalein | inhibition of 12-LOX enzymatic activity using baicalein inhibits MMP9 expression in PC3 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-3 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
12-LOX | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | 12-LOX-overexpressing PC-3 cells show an enhanced invasive ability which results from an increase in MMP9 expression and secretion | Homo sapiens |
physiological function | 12-LOX mediates the MMP9 secretion via activation of PI3K/Akt/NF-kappaB | Homo sapiens |