Literature summary for 1.13.11.31 extracted from

Yeung, J.; Apopa, P.L.; Vesci, J.; Stolla, M.; Rai, G.; Simeonov, A.; Jadhav, A.; Fernandez-Perez, P.; Maloney, D.J.; Boutaud, O.; Holman, T.R.; Holinstat, M.
12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity (2013), Thromb. Haemost., 110, 569-581.

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Inhibitors

Inhibitors	Comment	Organism	Structure
baicalein	12-LOX inhibition attenuates platelet aggregation	Homo sapiens
NCTT-956	12-LOX inhibition attenuates platelet aggregation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
12-LOX	-	Mus musculus
12-LOX	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	12-LOX inhibition attenuates platelet aggregation	Homo sapiens
malfunction	the time to cessation of bleeding in 12-LOX-/- mice is significantly prolonged. Mice deficient in 12-LOX show a significant attenuation of alphaIIbeta3 activation for both agonists compared to wild-type mice	Mus musculus
physiological function	inhibition of 12-LOX activity inhibits platelet aggregation, which is coupled to a significant shift in the ability of the platelet to induce normal integrin activation, dense granule secretion, and platelet adhesion under venous shear	Homo sapiens

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Release 2023.1 (January 2023)