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Literature summary for 1.13.11.33 extracted from
- Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase (2003), Biochemistry, 42, 5236-5243.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
General Stability
| General Stability | Organism |
|---|---|
| severe autoinactivation is observed at high substrate concentrations if the substrate is not HPLC-purified and stored at -80°C | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 4.2 | - |
O2 | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| reticulocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? | |
| linoleic acid + O2 | 4% of the activity with arachidonate | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 15-hLO | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 5.2 | - |
O2 | - |
Homo sapiens | |
| 10.2 | - |
linoleic acid | pH 7.5, 20°C | Homo sapiens | |
| 17.8 | - |
linoleic acid | pH 7.5, 30°C | Homo sapiens | |
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