Cloned (Comment) | Organism |
---|---|
15-LO-1 expressed in Sf 9 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | main distribution | Homo sapiens | 5829 | - |
membrane | the enzyme translocates to the membrane upon calcium challenge. In the presence of Ca2+/Mg2+, with or without calcium ionophore, the majority of 15-LO-1 is present in the membrane fraction | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | in the presence of Ca2+, with or without calcium ionophore, the majority of 15-LO-1 is found in the membrane fraction, although significant amounts are also detected in the supernatant fraction | Homo sapiens | |
Mg2+ | in the presence of Mg2+, with or without calcium ionophore, the majority of 15-LO-1 is found in the membrane fraction, although significant amounts are also detected in the supernatant fraction | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eosinophil | - |
Homo sapiens | - |
L-428 cell | - |
Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
additional information | high expression in L-1236 cells (Hodgkin Reed-Sternberg cells), present in HDLM2 cells and KMH2 cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-lipoxygenase-1 | - |
Homo sapiens |
15-LO-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the expression of 15-lipoxygenase-1 and the putative formation of eoxins by Hodgkin Reed-Sternberg cells in vivo are likely to contribute to the inflammatory features of Hodgkin lymphoma | Homo sapiens |