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Literature summary for 1.13.11.33 extracted from

  • Claesson, H.E.; Griffiths, W.J.; Brunnstroem, A.; Schain, F.; Andersson, E.; Feltenmark, S.; Johnson, H.A.; Porwit, A.; Sjoeberg, J.; Bjoerkholm, M.
    Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma (2008), FEBS J., 275, 4222-4234.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
15-LO-1 expressed in Sf 9 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol main distribution Homo sapiens 5829
-
membrane the enzyme translocates to the membrane upon calcium challenge. In the presence of Ca2+/Mg2+, with or without calcium ionophore, the majority of 15-LO-1 is present in the membrane fraction Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ in the presence of Ca2+, with or without calcium ionophore, the majority of 15-LO-1 is found in the membrane fraction, although significant amounts are also detected in the supernatant fraction Homo sapiens
Mg2+ in the presence of Mg2+, with or without calcium ionophore, the majority of 15-LO-1 is found in the membrane fraction, although significant amounts are also detected in the supernatant fraction Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
eosinophil
-
Homo sapiens
-
L-428 cell
-
Homo sapiens
-
macrophage
-
Homo sapiens
-
additional information high expression in L-1236 cells (Hodgkin Reed-Sternberg cells), present in HDLM2 cells and KMH2 cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
?

Synonyms

Synonyms Comment Organism
15-lipoxygenase-1
-
Homo sapiens
15-LO-1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the expression of 15-lipoxygenase-1 and the putative formation of eoxins by Hodgkin Reed-Sternberg cells in vivo are likely to contribute to the inflammatory features of Hodgkin lymphoma Homo sapiens