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Literature summary for 1.13.11.33 extracted from

  • Tang, Y.; Wang, M.T.; Chen, Y.; Yang, D.; Che, M.; Honn, K.V.; Akers, G.D.; Johnson, S.R.; Nie, D.
    Downregulation of vascular endothelial growth factor and induction of tumor dormancy by 15-lipoxygenase-2 in prostate cancer (2009), Int. J. Cancer, 124, 1545-1551.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine 15-LOX-2 is a negative regulator of tumor growth via downregulating angiogenesis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed as a fusion protein with GFP (pEGFP-15LOX-2) in DU145 and PC-3 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information is absent in prostate cancer cells Homo sapiens
-

Synonyms

Synonyms Comment Organism
15-lipoxygenase-2
-
Homo sapiens
15-LOX-2
-
Homo sapiens

General Information

General Information Comment Organism
physiological function 15-LOX-2 increases cell cycle arrest at G0/G1 phase. Injected into athymic nu/nu mice, prostate cancer cells with 15-LOX-2 expression can still form palpable tumors without significant changes in tumorigenicity. But, the tumors with 15-LOX-2 expression grow significantly slower than those derived from vector controls and are kept dormant for a long period of time. Increase in cell death in tumors derived from prostate cancer cells with 15- LOX-2 expression. 15-LOX-2 suppresses vascular endothelial growth factor A gene expression and sustains tumor dormancy in prostate cancer Homo sapiens