Literature summary for 1.13.11.34 extracted from

Abe, M.; Ozawa, Y.; Uda, Y.; Morimitsu, Y.; Nakamura, Y.; Osawa, T.
A novel labdane-type trialdehyde from myoga (Zingiber mioga Roscoe) that potently inhibits human platelet aggregation and human 5-lipoxygenase (2006), Biosci. Biotechnol. Biochem., 70, 2494-2500.

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Inhibitors

Inhibitors	Comment	Organism	Structure
miogadial	potent inhibitor, IC50: 0.004 mM	Homo sapiens
miogatrial	potent inhibitor, IC50: 0.0075 mM	Homo sapiens
additional information	no inhibition by galanal A, galanal B and 8beta(17)-epoxy-15-hydroxy-12(E)-labden-16-al	Homo sapiens
polygodial	strong inhibitory activity, IC50: 0.0086 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood platelet	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	-	Homo sapiens	(6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate	-	?

Synonyms

Synonyms	Comment	Organism
5-LOX	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.004	-	potent inhibitor, IC50: 0.004 mM	Homo sapiens	miogadial
0.0075	-	potent inhibitor, IC50: 0.0075 mM	Homo sapiens	miogatrial
0.0086	-	strong inhibitory activity, IC50: 0.0086 mM	Homo sapiens	polygodial

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Release 2023.1 (January 2023)