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Literature summary for 1.13.11.34 extracted from
- Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production (2006), Proc. Natl. Acad. Sci. USA, 103, 13150-13155.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| coactosin-like protein | stoichiometry 1:1 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| W13/75/102A | triple mutant shows higher total activity than the wild type enzyme | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 0.1 mM | Homo sapiens |  |
| Mg2+ | 5 mM activates 5LO in vitro in the presence of PC | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| MonoQ column chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + O2 | - |
Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5LO | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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