Activating Compound | Comment | Organism | Structure |
---|---|---|---|
(13S)-hydroperoxy-9,11-octadecadienoic acid | - |
Solanum tuberosum | |
(13S)-hydroperoxy-9,11-octadecadienoyl lysophosphatidylcholine | 50% activation concentration AC50 is 0.0015 mM | Solanum tuberosum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(15S)-hydroperoxy-5,8,11,13-eicosatetraenoyl lysophosphatidylcholine | - |
Solanum tuberosum | |
(17S)-hydroperoxy-4,7,10,13,15,19-docosahexaenoyl lysophosphatidylcholine | - |
Solanum tuberosum | |
arachidonoyl lysophosphatidylcholine | - |
Solanum tuberosum | |
additional information | no inhibition by 1-linoleoyl lysophosphatidylcholine and (13S)-hydroperoxy-9,11-octadecadienoyl lysophosphatidylcholine | Solanum tuberosum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | Solanum tuberosum | - |
leukotriene A4 + H2O | - |
? | |
arachidonic acid + O2 | Solanum tuberosum | - |
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Solanum tuberosum | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Solanum tuberosum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
Solanum tuberosum | leukotriene A4 + H2O | - |
? | |
arachidonic acid + O2 | - |
Solanum tuberosum | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5-lipoxygenase | - |
Solanum tuberosum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Solanum tuberosum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.3 | - |
assay at | Solanum tuberosum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics, overview | Solanum tuberosum | |
0.00038 | - |
arachidonoyl lysophosphatidylcholine | pH 6.3, 25°C | Solanum tuberosum | |
0.0019 | - |
(17S)-hydroperoxy-4,7,10,13,15,19-docosahexaenoyl lysophosphatidylcholine | pH 6.3, 25°C | Solanum tuberosum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0166 | - |
pH 6.3, 25°C | Solanum tuberosum | arachidonoyl lysophosphatidylcholine | |
0.0241 | - |
pH 6.3, 25°C | Solanum tuberosum | (17S)-hydroperoxy-4,7,10,13,15,19-docosahexaenoyl lysophosphatidylcholine |