Any feedback?
Literature summary for 1.13.11.34 extracted from
- Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors (2008), Prostaglandins Leukot. Essent. Fatty Acids, 78, 99-108.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| celecoxib | - |
Homo sapiens |  |
| CGP28238 | - |
Homo sapiens | |
| Cox-189 | - |
Homo sapiens | |
| diclofenac | - |
Homo sapiens | |
| eltenac | - |
Homo sapiens | |
| etoricoxib | - |
Homo sapiens | |
| meloxicam | - |
Homo sapiens | |
| MK-886 | - |
Homo sapiens | |
| ML-3000 | i.e. licofelone, ML-3000 has no effect on 5-LOX product synthesis in whole-blood assay, inhibition of COX pathways does not increase the transformation of arachidonic acid by the 5-LOX pathway | Homo sapiens | |
| nimesulide | - |
Homo sapiens | |
| parecoxib | - |
Homo sapiens | |
| rofecoxib | - |
Homo sapiens | |
| SC-560 | - |
Homo sapiens | |
| valdecoxib | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens | |
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | Homo sapiens | - |
leukotriene A4 + H2O | is unstable and metabolized to leukotriene B4 | ? | |
| arachidonic acid + O2 | Homo sapiens | - |
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
? | |
| additional information | Homo sapiens | inhibition of COX pathways does not increase the transformation of arachidonic acid by the 5-LOX pathway | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukocyte | polymorphonuclear | Homo sapiens | - |
| neutrophil | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
Homo sapiens | leukotriene A4 + H2O | - |
? | |
| (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
Homo sapiens | leukotriene A4 + H2O | is unstable and metabolized to leukotriene B4 | ? | |
| arachidonic acid + O2 | - |
Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
? | |
| additional information | inhibition of COX pathways does not increase the transformation of arachidonic acid by the 5-LOX pathway | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5-lipoxygenase | - |
Homo sapiens |
| 5-LOX | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| additional information | - |
inhibitory activity in polymorphonuclear leukocytes, overview | Homo sapiens | additional information | |
| 0.0032 | - |
37°C, whole blood assay | Homo sapiens | MK-886 | |
| 0.0195 | - |
37°C, whole blood assay | Homo sapiens | celecoxib | |
| 0.1 | - |
above, 37°C, whole blood assay | Homo sapiens | ML-3000 | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
