Application | Comment | Organism |
---|---|---|
medicine | IDO induces suppression of antitumoral immune response, inhibits tumor cell proliferation by tryptophan depletion | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Trp + O2 | Homo sapiens | the enzyme inhibits tumor cell proliferation by tryptophan depletion. IDO-induced suppression of antitumoral immune response in both adenocarcinoma and squamous cell carcinoma | L-formylkynurenine | - |
? | |
L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cervical cancer cell line | - |
Homo sapiens | - |
cervical carcinoma cell | - |
Homo sapiens | - |
endometrioid carcinoma cell | epithelium | Homo sapiens | - |
epithelium | of uterine endometrium and cervix | Homo sapiens | - |
additional information | cell in the peritumoral infiltrate of the stroma | Homo sapiens | - |
stromal cell | peritumoral infiltrate | Homo sapiens | - |
uterine cervix | epithelium | Homo sapiens | - |
uterine endometrium | epithelium | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Trp + O2 | the enzyme inhibits tumor cell proliferation by tryptophan depletion. IDO-induced suppression of antitumoral immune response in both adenocarcinoma and squamous cell carcinoma | Homo sapiens | L-formylkynurenine | - |
? | |
L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO | - |
Homo sapiens |
indoleamine 2,3-dioxygenase | - |
Homo sapiens |