Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cortisone | subcutaneously | Rattus norvegicus | |
D-tryptophan | 2g subcutaneously | Rattus norvegicus | |
hematine | - |
Rattus norvegicus | |
L-tryptophan | 2g subcutaneously | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | Rattus norvegicus | - |
N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | Rattus norvegicus | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
dialysis, lyophilization | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | intestinal mucosa of rat exhibits lower activity than in rabbit | Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000192 | - |
L-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, no rat-pretreatment | Rattus norvegicus |
0.000208 | - |
D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, no rat-pretreatment | Rattus norvegicus |
0.000224 | - |
D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with neomycin | Rattus norvegicus |
0.000245 | - |
L-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with cortisone | Rattus norvegicus |
0.000256 | - |
D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with cortisone | Rattus norvegicus |
0.000272 | - |
L-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with D-tryptophan | Rattus norvegicus |
0.000277 | - |
D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with D-tryptophan | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | - |
Rattus norvegicus | N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | - |
Rattus norvegicus | N-formyl-L-kynurenine | - |
? |