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Literature summary for 1.13.11.52 extracted from

  • Loh, H.H.; Berg, C.P.
    D-Tryptophan pyrrolase activity in the liver and the intestine of the rat (1972), J. Nutr., 102, 1331-1339.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cortisone subcutaneously Rattus norvegicus
D-tryptophan 2g subcutaneously Rattus norvegicus
hematine
-
Rattus norvegicus
L-tryptophan 2g subcutaneously Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-tryptophan + O2 Rattus norvegicus
-
N-formyl-D-kynurenine
-
?
L-tryptophan + O2 Rattus norvegicus
-
N-formyl-L-kynurenine
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
dialysis, lyophilization Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
intestine intestinal mucosa of rat exhibits lower activity than in rabbit Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000192
-
L-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, no rat-pretreatment Rattus norvegicus
0.000208
-
D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, no rat-pretreatment Rattus norvegicus
0.000224
-
D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with neomycin Rattus norvegicus
0.000245
-
L-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with cortisone Rattus norvegicus
0.000256
-
D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with cortisone Rattus norvegicus
0.000272
-
L-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with D-tryptophan Rattus norvegicus
0.000277
-
D-tryptophan, Tris-buffer, pH 8.0, 0.0001 mM methylene blue and 0.001 mM each of ATP and Mg2+, 37°C, 90 min, rat-pretreatment with D-tryptophan Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-tryptophan + O2
-
Rattus norvegicus N-formyl-D-kynurenine
-
?
L-tryptophan + O2
-
Rattus norvegicus N-formyl-L-kynurenine
-
?