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Literature summary for 1.13.11.52 extracted from

  • Matsuno, K.; Takai, K.; Isaka, Y.; Unno, Y.; Sato, M.; Takikawa, O.; Asai, A.
    S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase (2010), Bioorg. Med. Chem. Lett., 20, 5126-5129.
    View publication on PubMed
Search for more literature for 1.13.11.52

Inhibitors

Inhibitors Comment Organism Structure
(2,4-dichlorophenyl)methanethiol
-
 Homo sapiens
(2-chlorophenyl)methanethiol
-
 Homo sapiens
(3,4-dichlorophenyl)methanethiol
-
 Homo sapiens
(4-chlorophenyl)methanethiol
-
 Homo sapiens
(4-chlorophenyl)methanol
-
 Homo sapiens
(4-fluorophenyl)methanethiol
-
 Homo sapiens
(4-methoxyphenyl)methanethiol
-
 Homo sapiens
(4-methylphenyl)methanethiol
-
 Homo sapiens
1-(4-chlorobenzyl)urea
-
 Homo sapiens
1-(4-chlorophenyl)methanamine
-
 Homo sapiens
1-(4-chlorophenyl)thiourea
-
 Homo sapiens
1-[2-(4-chlorophenyl)ethyl]thiourea
-
 Homo sapiens
2,4-dichlorobenzyl carbamimidothioate hydrobromide
-
 Homo sapiens
2-(1H-imidazol-4-yl)phenol
-
 Homo sapiens
2-(2-chlorophenyl)ethyl carbamimidothioate hydrobromide
-
 Homo sapiens
2-(3-chlorophenyl)ethyl carbamimidothioate hydrobromide
-
 Homo sapiens
2-(4-chlorophenyl)ethanamine
-
 Homo sapiens
2-(4-chlorophenyl)ethyl carbamimidothioate hydrobromide
-
 Homo sapiens
2-chlorobenzyl carbamimidothioate hydrochloride
-
 Homo sapiens
3,4-dichlorobenzyl carbamimidothioate hydrochloride
-
 Homo sapiens
3-chlorobenzyl carbamimidothioate hydrochloride
-
 Homo sapiens
4-(phenylcarbonyl)benzyl carbamimidothioate hydrobromide
-
 Homo sapiens
4-(propan-2-yl)benzyl carbamimidothioate hydrobromide
-
 Homo sapiens
4-(trifluoromethyl)benzyl carbamimidothioate hydrochloride
-
 Homo sapiens
4-amino-N-benzyl-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
-
 Homo sapiens
4-bromobenzyl carbamimidothioate hydrobromide
-
 Homo sapiens
4-chlorobenzenesulfonic acid
-
 Homo sapiens
4-chlorobenzenethiol
-
 Homo sapiens
4-chlorobenzyl carbamimidothioate hydrochloride
-
 Homo sapiens
4-chlorobenzyl N,N'-dimethylcarbamimidothioate - 1-chlorotetraoxidane (1:1)
-
 Homo sapiens
4-cyanobenzyl carbamimidothioate hydrobromide
-
 Homo sapiens
4-ethylbenzyl carbamimidothioate hydrochloride
-
 Homo sapiens
4-fluorobenzyl carbamimidothioate hydrochloride
-
 Homo sapiens
4-methoxybenzyl carbamimidothioate hydrochloride
-
 Homo sapiens
4-methylbenzyl carbamimidothioate hydrochloride
-
 Homo sapiens
4-nitrobenzyl carbamimidothioate hydrochloride
-
 Homo sapiens
4-tert-butylbenzyl carbamimidothioate hydrobromide
-
 Homo sapiens
4-[(carbamimidoylsulfanyl)methyl]benzoic acid hydrochloride
-
 Homo sapiens
benzyl carbamimidothioate hydrochloride
-
 Homo sapiens
brassinin
-
 Homo sapiens
exiguamine A
-
 Homo sapiens
menadione
-
 Homo sapiens
methyl 4-[(carbamimidoylsulfanyl)methyl]benzenesulfinate hydrobromide
-
 Homo sapiens
methyl N-(4-chlorophenyl)carbamimidothioate hydroiodide
-
 Homo sapiens
methyl N-[2-(4-chlorophenyl)ethyl]carbamimidothioate hydroiodide
-
 Homo sapiens
phenylmethanethiol
-
 Homo sapiens
sodium 4-chlorobenzenesulfinate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
IDO
-
 Homo sapiens
indoleamine-2,3-dioxygenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens (3,4-dichlorophenyl)methanethiol
0.0004
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 2,4-dichlorobenzyl carbamimidothioate hydrobromide
0.0012
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens (2-chlorophenyl)methanethiol
0.0013
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-bromobenzyl carbamimidothioate hydrobromide
0.0013
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens (4-methylphenyl)methanethiol
0.0014
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens (4-methoxyphenyl)methanethiol
0.0017
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens phenylmethanethiol
0.0018
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens (4-fluorophenyl)methanethiol
0.0019
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-chlorobenzenethiol
0.0022
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-chlorobenzyl carbamimidothioate hydrochloride
0.0026
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-(trifluoromethyl)benzyl carbamimidothioate hydrochloride
0.0032
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens (4-chlorophenyl)methanethiol
0.0035
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens (2,4-dichlorophenyl)methanethiol
0.0046
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 3-chlorobenzyl carbamimidothioate hydrochloride
0.01
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 2-chlorobenzyl carbamimidothioate hydrochloride
0.011
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-nitrobenzyl carbamimidothioate hydrochloride
0.013
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-fluorobenzyl carbamimidothioate hydrochloride
0.016
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-ethylbenzyl carbamimidothioate hydrochloride
0.017
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 3,4-dichlorobenzyl carbamimidothioate hydrochloride
0.019
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-cyanobenzyl carbamimidothioate hydrobromide
0.021
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-chlorobenzyl N,N'-dimethylcarbamimidothioate - 1-chlorotetraoxidane (1:1)
0.03
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-methylbenzyl carbamimidothioate hydrochloride
0.052
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-methoxybenzyl carbamimidothioate hydrochloride
0.057
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 2-(4-chlorophenyl)ethyl carbamimidothioate hydrobromide
0.061
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens benzyl carbamimidothioate hydrochloride
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 1-(4-chlorophenyl)methanamine
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens (4-chlorophenyl)methanol
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-(propan-2-yl)benzyl carbamimidothioate hydrobromide
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-tert-butylbenzyl carbamimidothioate hydrobromide
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-[(carbamimidoylsulfanyl)methyl]benzoic acid hydrochloride
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens methyl 4-[(carbamimidoylsulfanyl)methyl]benzenesulfinate hydrobromide
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-(phenylcarbonyl)benzyl carbamimidothioate hydrobromide
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 2-(2-chlorophenyl)ethyl carbamimidothioate hydrobromide
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 2-(3-chlorophenyl)ethyl carbamimidothioate hydrobromide
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens methyl N-(4-chlorophenyl)carbamimidothioate hydroiodide
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens methyl N-[2-(4-chlorophenyl)ethyl]carbamimidothioate hydroiodide
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 1-(4-chlorophenyl)thiourea
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 1-(4-chlorobenzyl)urea
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 2-(4-chlorophenyl)ethanamine
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens sodium 4-chlorobenzenesulfinate
0.1
-
 IC50 above 0.1 mM, in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 4-chlorobenzenesulfonic acid
0.1
-
 in 50 mM potassium phosphate buffer (pH 6.5), 20 mM ascorbic acid (neutralized with NaOH and HCl), 0.01 mM methylene blue, at 37°C Homo sapiens 1-[2-(4-chlorophenyl)ethyl]thiourea