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Literature summary for 1.13.11.52 extracted from

  • Di Pucchio, T.; Danese, S.; De Cristofaro, R.; Rutella, S.
    Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds (2010), Expert Opin. Ther. Pat., 20, 229-250.
    View publication on PubMed
Search for more literature for 1.13.11.52

Inhibitors

Inhibitors Comment Organism Structure
1-methyl-D-tryptophan competitive inhibitor Homo sapiens
1-methyl-L-tryptophan competitive inhibitor Homo sapiens
4-amino-1,2,3-oxadiazole-3-carboximidamide
-
 Homo sapiens
annulin B
-
 Homo sapiens
beta-carboline
-
 Homo sapiens
brassinin
-
 Homo sapiens
epigallocatechin gallate
-
 Homo sapiens
exiguamine A
-
 Homo sapiens
exiguamine B
-
 Homo sapiens
menadione
-
 Homo sapiens
methyl-thiohydantoin-L-tryptophan competitive inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell
-
 Homo sapiens
-
fibroblast
-
 Homo sapiens
-
macrophage
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
IDO1
-
 Homo sapiens
indoleamine 2,3-dioxygenase 1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.019
-
 1-methyl-L-tryptophan pH and temperature not specified in the publication Homo sapiens
0.1
-
 1-methyl-D-tryptophan pH and temperature not specified in the publication Homo sapiens

Expression

Organism Comment Expression
Homo sapiens IDO expression is negatively regulated by interleukin-4, nitric oxide and transforming growth factor-beta down
Homo sapiens IDO expression is positively regulated by interferon-gamma, CD40 ligand, COX-2, lipopolysaccharide, tumor necrosis factor-alpha, and hepatocyte growth factor up

General Information

General Information Comment Organism
physiological function indoleamine 2,3-dioxygenase activity is implicated in the promotion of tolerance to tumors and in autoimmune and inflammatory conditions, itplays a role in arthritis, ischemia-reperfusion injury, haemostatic system, sepsis, atherosclerosis, diabetes, and gut, allergy, and airway inflammation Homo sapiens