Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | Mus musculus | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | - |
Mus musculus | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO1 | - |
Mus musculus |
indoleamine 2,3-dioxygenase 1 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | isozyme IDO 1 (but not isozyme IDO2) is induced specifically in the lungs of mice infected with Francisella novicida or Streptococcus pneumonia | up |
General Information | Comment | Organism |
---|---|---|
malfunction | the attenuation of Francisella novicida tryptophan mutant bacteria is rescued in the lungs of IDO1-deficient mice | Mus musculus |
physiological function | indoleamine 2,3-dioxygenase 1 is a lung-specific innate immune defense mechanism that inhibits growth of Francisella tularensis tryptophan auxotrophs | Mus musculus |