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Literature summary for 1.13.11.52 extracted from

  • Fu, X.; Zunich, S.M.; OConnor, J.C.; Kavelaars, A.; Dantzer, R.; Kelley, K.W.
    Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures (2010), J. Neuroinflammation, 7, 43.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Mus musculus
-
N-formyl-L-kynurenine
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
Mus musculus N-formyl-L-kynurenine
-
?

Synonyms

Synonyms Comment Organism
IDO
-
Mus musculus
indoleamine 2,3 dioxygenase
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
heme
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus transient stimulation of the innate immune system by an intraperitoneal injection of lipopolysaccharide (100 ng) activates peripheral and central expression of indoleamine 2,3 dioxygenase. Addition of lipopolysaccharide (10 ng/ml) to the medium of organotypic hippocampal slice cultures induces steady-state expression of mRNA transcripts for IDO that peaks at 6 h and translates into increased IDO enzymatic activity within 8 h post-lipopolysaccharide up

General Information

General Information Comment Organism
physiological function activation of IDO is a key event in the switch from sickness to depression, activation of the innate immune system in the brain is sufficient to activate IDO and to induce depressive-like behavior in the absence of detectable interferon-gamma Mus musculus