Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | Mus musculus | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | - |
Mus musculus | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO | - |
Mus musculus |
indoleamine 2,3 dioxygenase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | transient stimulation of the innate immune system by an intraperitoneal injection of lipopolysaccharide (100 ng) activates peripheral and central expression of indoleamine 2,3 dioxygenase. Addition of lipopolysaccharide (10 ng/ml) to the medium of organotypic hippocampal slice cultures induces steady-state expression of mRNA transcripts for IDO that peaks at 6 h and translates into increased IDO enzymatic activity within 8 h post-lipopolysaccharide | up |
General Information | Comment | Organism |
---|---|---|
physiological function | activation of IDO is a key event in the switch from sickness to depression, activation of the innate immune system in the brain is sufficient to activate IDO and to induce depressive-like behavior in the absence of detectable interferon-gamma | Mus musculus |