Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | not at a concentration of 0.5 mM: L-tryptophan, quinolinic acid, kynurenic acid, nicotinic acid mononucleotide, picolinic acid, phthalic acid, glutaric acid, L-aspartic acid, L-glutamic acid, N-methyl-D-aspartic acid, kainic acid | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | 0.0036 | 3-hydroxyanthranilic acid | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | requirement | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxyanthranilate + O2 | Rattus norvegicus | in mammalian peripheral organs the enzyme constitutes a link in the catabolic pathway of tryptophan to NAD+ | 2-amino-3-carboxymuconate semialdehyde | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | regional distribution | Rattus norvegicus | - |
Storage Stability | Organism |
---|---|
-80°C, as homogenate stable for 2 months | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxyanthranilate + O2 | high selectivity for substrate | Rattus norvegicus | 2-amino-3-carboxymuconate semialdehyde | reacts spontaneously to quinolinic acid | ? | |
3-hydroxyanthranilate + O2 | in mammalian peripheral organs the enzyme constitutes a link in the catabolic pathway of tryptophan to NAD+ | Rattus norvegicus | 2-amino-3-carboxymuconate semialdehyde | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.5 | 7 | at pH 4.5: about 70% of activity maximum, at pH 7.0: about 50% of activity maximum | Rattus norvegicus |