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Literature summary for 1.13.11.60 extracted from
- Linoleic acid 8R-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Mechanism of catalysis and inhibition (1994), Ann. N. Y. Acad. Sci., 744, 314-316.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| eicosatetraynoic acid | - |
Gaeumannomyces graminis |  |
| linoleate-hydroxamic acid | - |
Gaeumannomyces graminis | |
| N-[(E)-3-(3-phenoxyphenyl)prop-2-enyl]acetohydroxamic acid | i.e. BW A4C | Gaeumannomyces graminis | |
| nordihydroguaiaretic acid | - |
Gaeumannomyces graminis | |
| zileuton | - |
Gaeumannomyces graminis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| linoleate + O2 | Gaeumannomyces graminis | - |
(8R,10E,12Z)-8-hydroperoxy-10,12-octadecadienoate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gaeumannomyces graminis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| linoleate + O2 | - |
Gaeumannomyces graminis | (8R,10E,12Z)-8-hydroperoxy-10,12-octadecadienoate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 8R-DOX | - |
Gaeumannomyces graminis |
| linoleic acid 8R-dioxygenase | - |
Gaeumannomyces graminis |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0002 | - |
pH and temperature not specified in the publication | Gaeumannomyces graminis | N-[(E)-3-(3-phenoxyphenyl)prop-2-enyl]acetohydroxamic acid | |
| 0.003 | 0.01 | pH and temperature not specified in the publication | Gaeumannomyces graminis | zileuton | |
| 0.02 | - |
pH and temperature not specified in the publication | Gaeumannomyces graminis | linoleate-hydroxamic acid | |
| 0.09 | - |
pH and temperature not specified in the publication | Gaeumannomyces graminis | nordihydroguaiaretic acid | |
| 0.15 | - |
pH and temperature not specified in the publication | Gaeumannomyces graminis | eicosatetraynoic acid | |
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