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Literature summary for 1.14.11.1 extracted from

  • Lindstedt, S.; Nordin, I.
    Multiple forms of gamma-butyrobetaine hydroxylase (EC 1.14.11.1) (1984), Biochem. J., 223, 119-127.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.1

Inhibitors

Inhibitors Comment Organism Structure
DL-carnitine
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1 0.13 2-oxoglutarate gamma-butyrobetaine, values about the same for all three isozymes Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ requirement Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
64000
-
 gel filtration, 3 isozymes, detection by chromatofocusing and anion exchange chromatography Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 three isoforms
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.02 1.74 three isozymes of mammalian enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-trimethylammoniobutanoate + 2-oxoglutarate + O2
-
 Homo sapiens 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2
-
 ?

Subunits

Subunits Comment Organism
dimer SDS-PAGE, same value for all three isozymes, dimeric combinations of two subunits Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens