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Literature summary for 1.14.11.16 extracted from
- Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases (2004), Biochem. Soc. Trans., 32, 943-945.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | required | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptide L-asparagine + 2-oxoglutarate + O2 | Homo sapiens | enzyme catalyzes the erythro-beta-hydroxylation of asparaginyl and aspartyl residues to form the 2S, 3R-product, possible role in the Notch signalling pathway | peptide 3-hydroxy-L-asparagine + succinate + CO2 | - |
? | |
| peptide L-asparagine + 2-oxoglutarate + O2 | Homo sapiens | hydroxylation of Asn803 in hypoxia-inducible transcription factor, converted protein is incapable in interacting with the transcripitonal coactivator p300 | peptide 3-hydroxy-L-asparagine + succinate + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptide L-asparagine + 2-oxoglutarate + O2 | - |
Homo sapiens | peptide 3-hydroxy-L-asparagine + succinate + CO2 | - |
? | |
| peptide L-asparagine + 2-oxoglutarate + O2 | enzyme catalyzes the erythro-beta-hydroxylation of asparaginyl and aspartyl residues to form the 2S, 3R-product, possible role in the Notch signalling pathway | Homo sapiens | peptide 3-hydroxy-L-asparagine + succinate + CO2 | - |
? | |
| peptide L-asparagine + 2-oxoglutarate + O2 | hydroxylation of Asn803 in hypoxia-inducible transcription factor, converted protein is incapable in interacting with the transcripitonal coactivator p300 | Homo sapiens | peptide 3-hydroxy-L-asparagine + succinate + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | homodimer, crystal structure analysis | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EGF beta-hydroxylase | - |
Homo sapiens |
| EGFH | - |
Homo sapiens |
| factor inhibiting hypoxia-inducible transcription factor (HIF) | - |
Homo sapiens |
| FIH | - |
Homo sapiens |
| human aspartyl (asparaginyl) beta-hydroxylase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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