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Literature summary for 1.14.11.16 extracted from

  • Linke, S.; Stojkoski, C.; Kewley, R.J.; Booker, G.W.; Whitelaw, M.L.; Peet, D.J.
    Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor (2004), J. Biol. Chem., 279, 14391-14397.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK293T cells and in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptide L-asparagine + 2-oxoglutarate + O2 Homo sapiens hydroxylation of Asn803 in hypoxia-inducible transcription factor, converted protein is incapable in interacting with the transcripitonal coactivator p300 peptide 3-hydroxy-L-asparagine + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
HIF (L-Asn803) + 2-oxoglutarate + O2 accepts HIF-1alpha and HIF-2-alpha as substrate, HIF mutant V802A exhibits 4fold lower substrate activity than native protein, no activity with N803A mutant Homo sapiens HIF (3-hydroxy-L-Asn803) + succinate + CO2
-
?
peptide L-asparagine + 2-oxoglutarate + O2
-
Homo sapiens peptide 3-hydroxy-L-asparagine + succinate + CO2
-
?
peptide L-asparagine + 2-oxoglutarate + O2 hydroxylation of Asn803 in hypoxia-inducible transcription factor, converted protein is incapable in interacting with the transcripitonal coactivator p300 Homo sapiens peptide 3-hydroxy-L-asparagine + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
factor inhibiting hypoxia-inducible transcription factor (HIF)
-
Homo sapiens
FIH
-
Homo sapiens