Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ascorbate | 2.5fold induction at 5 mM | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | not inhibited by bifonazole, clotrimazole, miconazole, ketoconazole | Homo sapiens | |
propyl gallate | no activity with 1 mM, interacts with iron binding | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.049 | - |
2-oxoglutarate | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | requirement | Homo sapiens | |
Fe2+ | optimal activity at 0.5 mM | Homo sapiens | |
additional information | Cu2+, Mn2+ or Zn2+ can not replace Fe2+ | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000041 | - |
in liver homogenate | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phytanoyl-CoA + 2-oxoglutarate + O2 | - |
Homo sapiens | alpha-hydroxyphytanoyl-CoA + succinate + CO2 | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 8.5 | at pH 6.5 over 80%, at pH 8.5 50% of control activity | Homo sapiens |