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Literature summary for 1.14.11.2 extracted from

  • De Waal, A.; Hartog, A.F.; de Jong, L.
    Localisation and quantification of the 2-oxoglutarate binding sites of prolyl 4-hydroxylase by photoaffinity labeling with tritiated 5-azidopyridine-2-carboxylic acid (1988), Biochim. Biophys. Acta, 953, 20-25.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
5-Azidopyridine-2-carboxylic acid incorporated in the alpha subunit of the enzyme, complete inactivation of the enzyme by incorporation of 2 mol of photoaffinity label per mol of tetramer Gallus gallus
pyridine 2-carboxylate
-
Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proline containing peptide + 2-oxoglutarate + O2 chelation to the enzyme-bound metal ion is important for proper binding of the substrate 2-oxoglutarate Gallus gallus 4-hydroxyproline containing peptide + succinate + CO2
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.09
-
5-Azidopyridine-2-carboxylic acid
-
Gallus gallus