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Literature summary for 1.14.11.2 extracted from

  • Hutton, J.J.; Tappel, A.L.; Udenfried, S.
    Cofactor and substrate requirements of collagen proline hydroxylase (1967), Arch. Biochem. Biophys., 118, 231-240.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 91% inhibition at 0.02 mM Rattus norvegicus
2,2'-dipyridyl
-
Gallus gallus
2,2'-dipyridyl 87% inhibition at 0.02 mM Rattus norvegicus
antimycin A 18% inhibition at 0.02 mM Rattus norvegicus
Cupferron 28% inhibition at 0.02 mM Rattus norvegicus
diethyldithiocarbamate 10% inhibition at 0.02 mM Rattus norvegicus
EDTA
-
Gallus gallus
EDTA 64% inhibition at 0.02 mM Rattus norvegicus
gelatin commercial, inhibitor Cavia porcellus
gelatin commercial, inhibitor Gallus gallus
gelatin commercial, inhibitor Rattus norvegicus
Ketomalonate 100% inhibition at 1 mM, acts by chelating ferrous ion rather than by competing with alpha-ketoglutarate Cavia porcellus
Ketomalonate 100% inhibition at 1 mM, acts by chelating ferrous ion rather than by competing with alpha-ketoglutarate Gallus gallus
Ketomalonate 100% inhibition at 1 mM, acts by chelating ferrous ion rather than by competing with alpha-ketoglutarate Rattus norvegicus
malonate 19% inhibition at 1 mM Cavia porcellus
malonate 19% inhibition at 1 mM Gallus gallus
malonate 19% inhibition at 1 mM Rattus norvegicus
oxalate 34% inhibition at 1 mM Cavia porcellus
oxalate 34% inhibition at 1 mM Gallus gallus
oxalate 34% inhibition at 1 mM Rattus norvegicus
propyl gallate 100% inhibition at 2 mM Cavia porcellus
propyl gallate 100% inhibition at 2 mM Gallus gallus
propyl gallate 100% inhibition at 2 mM Rattus norvegicus
succinate 51% inhibition at 1 mM Cavia porcellus
succinate 51% inhibition at 1 mM Gallus gallus
succinate 51% inhibition at 1 mM Rattus norvegicus
trifluorothienylbutanedione 48% inhibition at 0.05 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
O2
-
Gallus gallus
0.03
-
O2
-
Rattus norvegicus
0.03
-
peptidyl L-proline
-
Cavia porcellus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ no compound can replace Fe2+, Km: 0.03 mM Gallus gallus
Fe2+ no compound can replace Fe2+, Km: 0.03 mM Cavia porcellus
Fe2+ no compound can replace Fe2+, Km: 0.03 mM Rattus norvegicus
Mg2+ 3% relative activity with respect to Fe2+ Gallus gallus
Mn2+ 10% relative activity with respect to Fe2+ Gallus gallus

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Gallus gallus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Gallus gallus
-
skin
-
Gallus gallus
-
skin fetus Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidyl L-proline + 2-oxoglutarate + O2
-
Cavia porcellus peptidyl-trans-4-hydroxy-L-proline + succinate + CO2
-
r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
-
Gallus gallus
30
-
-
Cavia porcellus
30
-
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
2-oxoglutarate no compound can replace alpha-ketoglutarate Gallus gallus
2-oxoglutarate no compound can replace alpha-ketoglutarate Cavia porcellus
2-oxoglutarate no compound can replace alpha-ketoglutarate Rattus norvegicus
ascorbate requirement Gallus gallus
ascorbate requirement Cavia porcellus
ascorbate requirement Rattus norvegicus
ascorbate Km: 0.2-1 mM, dependent on the concentrations of alpha-ketoglutarate and Fe2+, reduced pteridines can partially replace ascorbate Gallus gallus
ascorbate Km: 0.2-1 mM, dependent on the concentrations of alpha-ketoglutarate and Fe2+, reduced pteridines can partially replace ascorbate Cavia porcellus
ascorbate Km: 0.2-1 mM, dependent on the concentrations of alpha-ketoglutarate and Fe2+, reduced pteridines can partially replace ascorbate Rattus norvegicus
D-isoascorbate can replace ascorbate Gallus gallus
D-isoascorbate can replace ascorbate Cavia porcellus
D-isoascorbate can replace ascorbate Rattus norvegicus