Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | 91% inhibition at 0.02 mM | Rattus norvegicus | |
2,2'-dipyridyl | - |
Gallus gallus | |
2,2'-dipyridyl | 87% inhibition at 0.02 mM | Rattus norvegicus | |
antimycin A | 18% inhibition at 0.02 mM | Rattus norvegicus | |
Cupferron | 28% inhibition at 0.02 mM | Rattus norvegicus | |
diethyldithiocarbamate | 10% inhibition at 0.02 mM | Rattus norvegicus | |
EDTA | - |
Gallus gallus | |
EDTA | 64% inhibition at 0.02 mM | Rattus norvegicus | |
gelatin | commercial, inhibitor | Cavia porcellus | |
gelatin | commercial, inhibitor | Gallus gallus | |
gelatin | commercial, inhibitor | Rattus norvegicus | |
Ketomalonate | 100% inhibition at 1 mM, acts by chelating ferrous ion rather than by competing with alpha-ketoglutarate | Cavia porcellus | |
Ketomalonate | 100% inhibition at 1 mM, acts by chelating ferrous ion rather than by competing with alpha-ketoglutarate | Gallus gallus | |
Ketomalonate | 100% inhibition at 1 mM, acts by chelating ferrous ion rather than by competing with alpha-ketoglutarate | Rattus norvegicus | |
malonate | 19% inhibition at 1 mM | Cavia porcellus | |
malonate | 19% inhibition at 1 mM | Gallus gallus | |
malonate | 19% inhibition at 1 mM | Rattus norvegicus | |
oxalate | 34% inhibition at 1 mM | Cavia porcellus | |
oxalate | 34% inhibition at 1 mM | Gallus gallus | |
oxalate | 34% inhibition at 1 mM | Rattus norvegicus | |
propyl gallate | 100% inhibition at 2 mM | Cavia porcellus | |
propyl gallate | 100% inhibition at 2 mM | Gallus gallus | |
propyl gallate | 100% inhibition at 2 mM | Rattus norvegicus | |
succinate | 51% inhibition at 1 mM | Cavia porcellus | |
succinate | 51% inhibition at 1 mM | Gallus gallus | |
succinate | 51% inhibition at 1 mM | Rattus norvegicus | |
trifluorothienylbutanedione | 48% inhibition at 0.05 mM | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.03 | - |
O2 | - |
Gallus gallus | |
0.03 | - |
O2 | - |
Rattus norvegicus | |
0.03 | - |
peptidyl L-proline | - |
Cavia porcellus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | no compound can replace Fe2+, Km: 0.03 mM | Gallus gallus | |
Fe2+ | no compound can replace Fe2+, Km: 0.03 mM | Cavia porcellus | |
Fe2+ | no compound can replace Fe2+, Km: 0.03 mM | Rattus norvegicus | |
Mg2+ | 3% relative activity with respect to Fe2+ | Gallus gallus | |
Mn2+ | 10% relative activity with respect to Fe2+ | Gallus gallus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Gallus gallus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Gallus gallus | - |
skin | - |
Gallus gallus | - |
skin | fetus | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidyl L-proline + 2-oxoglutarate + O2 | - |
Cavia porcellus | peptidyl-trans-4-hydroxy-L-proline + succinate + CO2 | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
- |
Gallus gallus |
30 | - |
- |
Cavia porcellus |
30 | - |
- |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
2-oxoglutarate | no compound can replace alpha-ketoglutarate | Gallus gallus | |
2-oxoglutarate | no compound can replace alpha-ketoglutarate | Cavia porcellus | |
2-oxoglutarate | no compound can replace alpha-ketoglutarate | Rattus norvegicus | |
ascorbate | requirement | Gallus gallus | |
ascorbate | requirement | Cavia porcellus | |
ascorbate | requirement | Rattus norvegicus | |
ascorbate | Km: 0.2-1 mM, dependent on the concentrations of alpha-ketoglutarate and Fe2+, reduced pteridines can partially replace ascorbate | Gallus gallus | |
ascorbate | Km: 0.2-1 mM, dependent on the concentrations of alpha-ketoglutarate and Fe2+, reduced pteridines can partially replace ascorbate | Cavia porcellus | |
ascorbate | Km: 0.2-1 mM, dependent on the concentrations of alpha-ketoglutarate and Fe2+, reduced pteridines can partially replace ascorbate | Rattus norvegicus | |
D-isoascorbate | can replace ascorbate | Gallus gallus | |
D-isoascorbate | can replace ascorbate | Cavia porcellus | |
D-isoascorbate | can replace ascorbate | Rattus norvegicus |