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Literature summary for 1.14.11.2 extracted from

  • Vasta, J.D.; Higgin, J.J.; Kersteen, E.A.; Raines, R.T.
    Bioavailable affinity label for collagen prolyl 4-hydroxylase (2013), Bioorg. Med. Chem., 21, 3597-3601.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-oxo-5,6-epoxyhexanoate Caenorhabditis elegans exposed to the esterified epoxy ketone displays the phenotype of a worm lacking P4H Caenorhabditis elegans
4-oxo-5,6-epoxyhexanoate
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dansyl-Gly-Phe-Pro-Gly-OEt + 2-oxoglutarate + O2
-
Homo sapiens dansyl-Gly-Phe-4-hydroxy-L-Pro-Gly-OEt + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
collagen prolyl 4-hydroxylase
-
Homo sapiens
collagen prolyl 4-hydroxylase
-
Caenorhabditis elegans
P4H
-
Homo sapiens
P4H
-
Caenorhabditis elegans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
assay at Homo sapiens