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Literature summary for 1.14.11.21 extracted from

  • Zhang, Z.; Ren, J.; Stammers, D.K.; Baldwin, J.E.; Harlos, K.; Schofield, C.J.
    Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase (2000), Nat. Struct. Biol., 7, 127-133.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
recombinant isozyme CAS1, hanging drop method, 2 M ammonium sulfate, 0.1 M Tris, 21°C, apoform crystals or in complex with Fe2+, N-alpha-acetyl-L-arginine, and the substrates 2-oxoglutarate and proclavaminate, X-ray diffraction structure determination for native and heavy atom derivatives and analysis Streptomyces clavuligerus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
Streptomyces clavuligerus

Organism

Organism UniProt Comment Textmining
Streptomyces clavuligerus Q05581 recombinant CAS1
-
Streptomyces clavuligerus Q05581 crystal structure of isozyme CAS1, complexed or uncomplexed, recombinant from Escherichia coli, Protein Data Bank: 1DS0, 1DS1, 1DRY, 1DRT, 1GVG
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Reaction

Reaction Comment Organism Reaction ID
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O reaction mechanism Streptomyces clavuligerus
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O substrate-binding mechanism Streptomyces clavuligerus
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O reaction mechanism Streptomyces clavuligerus
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O substrate-binding mechanism Streptomyces clavuligerus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 this reaction is due to a proclavaminate amidinohydrolase, i.e. cla Streptomyces clavuligerus amidinoproclavaminate + succinate + CO2 + H2O
-
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2 hydroxylation Streptomyces clavuligerus guanidinoproclavaminate + succinate + CO2 + H2O
-
?
dihydroclavaminate + 2-oxoglutarate + O2 cyclization Streptomyces clavuligerus clavaminate + succinate + CO2 + H2O
-
?
additional information substrate-binding Streptomyces clavuligerus ?
-
?
additional information dependent on O2 and 2-oxoglutarate Streptomyces clavuligerus ?
-
?
N-alpha-acetyl-L-arginine + 2-oxoglutarate + O2 hydroxylation Streptomyces clavuligerus 4-hydroxy-N-alpha-acetyl-L-arginine + succinate + CO2 + H2O
-
?
N-alpha-acetyl-L-arginine + 2-oxoglutarate + O2 isozyme CAS1 Streptomyces clavuligerus 4-hydroxy-N-alpha-acetyl-L-arginine + succinate + CO2 + H2O
-
?
proclavaminate + 2-oxoglutarate + O2 saturation Streptomyces clavuligerus dihydroclavaminate + succinate + CO2 + H2O
-
?

Synonyms

Synonyms Comment Organism
CAS
-
Streptomyces clavuligerus