Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.27 extracted from

  • He, J.; Kallin, E.M.; Tsukada, Y.; Zhang, Y.
    The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b) (2008), Nat. Struct. Mol. Biol., 15, 1169-1175.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.27

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis by quantitative reverse transcriptase PCR, overexpression of wild-type Jhdm1b in HeLa and HEK293 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
H211A inactive mutant Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus substrate specificity of Jhdm1b in vivo using HEK293 cells overexpressing the enzyme, overview ?
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 Mus musculus the effect of Jhdm1b on cell proliferation and cellular senescence is mediated through de-repression of p15Ink4b as loss of p15Ink4b function rescues cell proliferation defects in Jhdm1b knockdown cells [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q6P1G2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast embryonic Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information substrate specificity of Jhdm1b in vivo using HEK293 cells overexpressing the enzyme, overview Mus musculus ?
-
 ?
additional information Jhdm1b, like its paralogue, JHDM1A, can specifically demethylate H3K36me2 and H3K36me1 histone substrates, but they are not active on methylated Lys4 Mus musculus ?
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2
-
 Mus musculus [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 the effect of Jhdm1b on cell proliferation and cellular senescence is mediated through de-repression of p15Ink4b as loss of p15Ink4b function rescues cell proliferation defects in Jhdm1b knockdown cells Mus musculus [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Synonyms

Synonyms Comment Organism
H3K36 demethylase
-
 Mus musculus
H3K36me2-specific demethylase
-
 Mus musculus
JHDM1A
-
 Mus musculus
Jhdm1b/Kdm2b
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus knockdown of Jhdm1b in primary mouse embryonic fibroblasts inhibits cell proliferation and induces cellular senescence in a pRb and p53 pathway-dependent manner. The effect of Jhdm1b on cell proliferation and cellular senescence is mediated through de-repression of p15Ink4b as loss of p15Ink4b function rescues cell proliferation defects in Jhdm1b knockdown cells down

General Information

General Information Comment Organism
physiological function the H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b), Jhdm1b targets the p15Ink4b locus and regulates its expression in an enzymatic activity-dependent manner, overview Mus musculus