Cloned (Comment) | Organism |
---|---|
expression of GFP-tagged Jmjd6 in HEK-293 cells, GFP pulldown interaction analysis with U2AF65, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | dependent on | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine-[U2AF65] + 2-oxoglutarate + O2 | Homo sapiens | U2AF65 is the splicing factor U2 small nuclear ribonucleoprotein auxiliary factor 65-kDa subunit, which undergoes posttranslational lysyl-5-hydroxylation catalyzed by the Fe2+ and 2-oxoglutarate-dependent dioxygenase Jumonji domain-6 protein Jmjd6, a nuclear protein that has an important role in vertebrate development and is a human homologue of the HIF asparaginyl-hydroxylase | 5-hydroxy-L-lysine-[U2AF65] + succinate + CO2 | - |
? | |
additional information | Homo sapiens | Jmjd6 changes alternative RNA splicing of some, but not all, of the endogenous and reporter genes, supporting a specific role for Jmjd6 in the regulation of RNA splicing, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | posttranslational hydroxylation in both the cytoplasm and the nucleoplasm is ubiquitous | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine-[U2AF65] + 2-oxoglutarate + O2 | U2AF65 is the splicing factor U2 small nuclear ribonucleoprotein auxiliary factor 65-kDa subunit, which undergoes posttranslational lysyl-5-hydroxylation catalyzed by the Fe2+ and 2-oxoglutarate-dependent dioxygenase Jumonji domain-6 protein Jmjd6, a nuclear protein that has an important role in vertebrate development and is a human homologue of the HIF asparaginyl-hydroxylase | Homo sapiens | 5-hydroxy-L-lysine-[U2AF65] + succinate + CO2 | - |
? | |
L-lysine-[U2AF65] + 2-oxoglutarate + O2 | U2AF65 is the splicing factor U2 small nuclear ribonucleoprotein auxiliary factor 65-kilodalton subunit | Homo sapiens | 5-hydroxy-L-lysine-[U2AF65] + succinate + CO2 | - |
? | |
additional information | Jmjd6 changes alternative RNA splicing of some, but not all, of the endogenous and reporter genes, supporting a specific role for Jmjd6 in the regulation of RNA splicing, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Jmjd6 | - |
Homo sapiens |