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Literature summary for 1.14.11.6 extracted from
- A kinetic study of thymine 7-hydroxylase from Neurospora crassa (1975), Biochemistry, 14, 4999-5003.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-Carboxyuracil | - |
Neurospora crassa |  |
| 5-Hydroxymethyluracil | competitive inhibitor against thymine, noncompetitive against oxygen | Neurospora crassa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-formyluracil + 2-oxoglutarate + O2 | Neurospora crassa | - |
5-carboxyuracil + succinate + CO2 | - |
? | |
| 5-formyluracil + 2-oxoglutarate + O2 | Neurospora crassa STA 4 | - |
5-carboxyuracil + succinate + CO2 | - |
? | |
| 5-hydroxymethyluracil + 2-oxoglutarate + O2 | Neurospora crassa | - |
5-formyluracil + succinate + CO2 | - |
? | |
| 5-hydroxymethyluracil + 2-oxoglutarate + O2 | Neurospora crassa STA 4 | - |
5-formyluracil + succinate + CO2 | - |
? | |
| thymine + 2-oxoglutarate + O2 | Neurospora crassa | - |
5-hydroxymethyluracil + succinate + CO2 | - |
? | |
| thymine + 2-oxoglutarate + O2 | Neurospora crassa STA 4 | - |
5-hydroxymethyluracil + succinate + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Neurospora crassa | - |
STA 4 | - |
| Neurospora crassa STA 4 | - |
STA 4 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-formyluracil + 2-oxoglutarate + O2 | - |
Neurospora crassa | 5-carboxyuracil + succinate + CO2 | - |
? | |
| 5-formyluracil + 2-oxoglutarate + O2 | - |
Neurospora crassa STA 4 | 5-carboxyuracil + succinate + CO2 | - |
? | |
| 5-hydroxymethyluracil + 2-oxoglutarate + O2 | - |
Neurospora crassa | 5-formyluracil + succinate + CO2 | - |
? | |
| 5-hydroxymethyluracil + 2-oxoglutarate + O2 | - |
Neurospora crassa STA 4 | 5-formyluracil + succinate + CO2 | - |
? | |
| thymine + 2-oxoglutarate + O2 | - |
Neurospora crassa | 5-hydroxymethyluracil + succinate + CO2 | - |
? | |
| thymine + 2-oxoglutarate + O2 | - |
Neurospora crassa STA 4 | 5-hydroxymethyluracil + succinate + CO2 | - |
? | |
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