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Literature summary for 1.14.11.8 extracted from
- Functional analysis of TMLH variants and definition of domains required for catalytic activity and mitochondrial targeting (2005), J. Cell. Physiol., 204, 839-847.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 2-oxoglutarate | dependent | Mus musculus |  |
| 2-oxoglutarate | dependent | Homo sapiens | |
| Fe2+ | dependent | Mus musculus | |
| Fe2+ | dependent | Homo sapiens | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in COS-1 cells | Mus musculus |
| expressed in COS-1 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| H389L | enzyme not functional | Mus musculus |
| H389L | enzyme not functional | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| heart | - |
Mus musculus | - |
| heart | - |
Homo sapiens | - |
| intestine | - |
Homo sapiens | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| muscle | - |
Mus musculus | - |
| muscle | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| testis | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 | - |
Mus musculus | 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 | - |
? | |
| N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 | - |
Homo sapiens | 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| eta-N-trimethyllysine hydroxylase | - |
Mus musculus |
| eta-N-trimethyllysine hydroxylase | - |
Homo sapiens |
| TMLH | - |
Mus musculus |
| TMLH | - |
Homo sapiens |
| TMLH-a | - |
Mus musculus |
| TMLH-a | - |
Homo sapiens |
| TMLH-b | - |
Mus musculus |
| TMLH-b | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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