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Literature summary for 1.14.12.12 extracted from

  • Lee, K
    Benzene-induced uncoupling of naphthalene dioxygenase activity and enzyme inactivation by production of hydrogen peroxide (1999), J. Bacteriol., 181, 2719-2725.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
H2O2 0.4 mM, complete inactivation of reduced terminal dioxygenase ISPNAP after 10 min in the absence of ferrous iron Pseudomonas sp.

Organism

Organism UniProt Comment Textmining
Pseudomonas sp.
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strain NCIB 9816/11, naphthalene dihydrogenase mutant derived from strain NCIB 9816-4 oxidizing naphthalene to cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzene + NADH + O2 40-50% of O2 is reduced to H2O2 by an uncoupling reaction, only trace amounts of cis-benzene-1,2-dihydrodiol are formed Pseudomonas sp. H2O2 + cis-benzene-1,2-dihydrodiol + NAD+
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