Inhibitors | Comment | Organism | Structure |
---|---|---|---|
clotrimazole | - |
Candida albicans | |
clotrimazole | - |
Escherichia coli | |
clotrimazole | - |
Saccharomyces cerevisiae | |
econazole | - |
Candida albicans | |
econazole | - |
Escherichia coli | |
econazole | - |
Saccharomyces cerevisiae | |
imidazole | imidazoles coordinate the heme iron atom, impair ferric heme reduction, produce uncompetitive inhibition with respect to O2 and NO and inhibit NO metabolism | Candida albicans | |
imidazole | imidazoles coordinate the heme iron atom, impair ferric heme reduction, produce uncompetitive inhibition with respect to O2 and NO and inhibit NO metabolism | Escherichia coli | |
imidazole | imidazoles coordinate the heme iron atom, impair ferric heme reduction, produce uncompetitive inhibition with respect to O2 and NO and inhibit NO metabolism | Saccharomyces cerevisiae | |
ketoconazole | - |
Candida albicans | |
ketoconazole | - |
Escherichia coli | |
ketoconazole | - |
Saccharomyces cerevisiae | |
miconazole | competitive with respect to O2 and NO | Candida albicans | |
miconazole | competitive with respect to O2 and NO | Escherichia coli | |
miconazole | competitive with respect to O2 and NO | Saccharomyces cerevisiae | |
NO | high concentrations, competition with O2, augmented by miconazole | Candida albicans | |
NO | high concentrations, competition with O2, augmented by miconazole | Escherichia coli | |
NO | high concentrations, competition with O2, augmented by miconazole | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
- |
- |
Escherichia coli | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NO + O2 + NADH | - |
Escherichia coli | NO3- + NAD+ | - |
? | |
NO + O2 + NADH | - |
Saccharomyces cerevisiae | NO3- + NAD+ | - |
? | |
NO + O2 + NADH | - |
Candida albicans | NO3- + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
flavohemoglobin | - |
Escherichia coli |
flavohemoglobin | - |
Saccharomyces cerevisiae |
flavohemoglobin | - |
Candida albicans |
NOD | - |
Escherichia coli |
NOD | - |
Saccharomyces cerevisiae |
NOD | - |
Candida albicans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Escherichia coli | |
NADH | - |
Saccharomyces cerevisiae | |
NADH | - |
Candida albicans |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00008 | - |
miconazole | - |
Escherichia coli | |
0.000225 | - |
econazole | - |
Candida albicans | |
0.00055 | - |
econazole | - |
Escherichia coli | |
0.00065 | - |
clotrimazole | - |
Candida albicans | |
0.0007 | - |
miconazole | - |
Candida albicans | |
0.0013 | - |
clotrimazole | - |
Escherichia coli | |
0.005 | - |
ketoconazole | - |
Escherichia coli | |
0.012 | - |
miconazole | - |
Saccharomyces cerevisiae | |
0.0125 | - |
ketoconazole | - |
Candida albicans | |
0.03 | - |
econazole | - |
Saccharomyces cerevisiae | |
0.05 | - |
clotrimazole | - |
Saccharomyces cerevisiae | |
0.1 | - |
ketoconazole | - |
Saccharomyces cerevisiae |