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Literature summary for 1.14.13.148 extracted from

  • Koukouritaki, S.; Poch, M.; Cabacungan, E.; McCarver, D.; Hines, R.
    Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants (2005), Mol. Pharmacol., 68, 383-392.
    View publication on PubMed
Search for more literature for 1.14.13.148

Protein Variants

Protein Variants Comment Organism
E158K the mutant shows reduced FMO3 activity Homo sapiens
E24D the mutation impacts the structure of the Rossmann fold involved in FAD binding and does not alter FMO3 catalytic activity Homo sapiens
E308G the mutant shows reduced FMO3 activity Homo sapiens
K416N the mutation has minimal impact on either hydrophilicity or protein structure Homo sapiens
N61K the mutation disrupts the secondary structure of a conserved membrane interaction domain and does not alter FMO3 catalytic activity Homo sapiens
V257M the mutant shows reduced FMO3 activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P31513
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
EC 1.14.13.8 assigned to Homo sapiens
flavin-containing monooxygenase 3
-
 Homo sapiens
FMO3
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
NADPH required for activity Homo sapiens