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Literature summary for 1.14.13.22 extracted from
- Enhanced production of epsilon-caprolactone by overexpression of NADPH-regenerating glucose 6-phosphate dehydrogenase in recombinant Escherichia coli harboring cyclohexanone monooxygenase gene (2007), Appl. Microbiol. Biotechnol., 76, 329-338.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli, optimization of CHMO expression conditions, high concentrations of cyclohexanone cause the formation of CHMO as inclusion bodies during the reaction period, co-expression with the NADPH-regenerating enzyme glucose 6-phosphate dehydrogenase, overview | Acinetobacter calcoaceticus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cyclohexanone | substrate inhibition | Acinetobacter calcoaceticus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cyclohexanone + NADPH + H+ + O2 | Acinetobacter calcoaceticus | - |
epsilon-caprolactone + NADP+ + H2O | - |
? | |
| cyclohexanone + NADPH + H+ + O2 | Acinetobacter calcoaceticus NCIMB 9871 | - |
epsilon-caprolactone + NADP+ + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acinetobacter calcoaceticus | - |
- |
- |
| Acinetobacter calcoaceticus NCIMB 9871 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cyclohexanone + NADPH + H+ + O2 | - |
Acinetobacter calcoaceticus | epsilon-caprolactone + NADP+ + H2O | - |
? | |
| cyclohexanone + NADPH + H+ + O2 | - |
Acinetobacter calcoaceticus NCIMB 9871 | epsilon-caprolactone + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CHMO | - |
Acinetobacter calcoaceticus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Acinetobacter calcoaceticus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Acinetobacter calcoaceticus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Acinetobacter calcoaceticus | |
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Release 2023.1 (January 2023)
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