Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Methylococcus capsulatus |
expressed in Escherichia coli | Methylomicrobium album |
expressed in Escherichia coli | Methylocystis sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | copper ions irreversibly inhibit the activity of sMMO in vivo and in vitro by inactivating the reductase component | Methylococcus capsulatus | |
Cu2+ | copper ions irreversibly inhibit the activity of sMMO in vivo and in vitro by inactivating the reductase component | Methylocystis sp. | |
Cu2+ | copper ions irreversibly inhibit the activity of sMMO in vivo and in vitro by inactivating the reductase component | Methylomicrobium album |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Methylococcus capsulatus | 5737 | - |
cytoplasm | - |
Methylomicrobium album | 5737 | - |
cytoplasm | - |
Methylocystis sp. | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
methane + duroquinol + O2 | Methylococcus capsulatus | - |
methanol + duroquinone + H2O | - |
? | |
methane + duroquinol + O2 | Methylomicrobium album | - |
methanol + duroquinone + H2O | - |
? | |
methane + duroquinol + O2 | Methylocystis sp. | - |
methanol + duroquinone + H2O | - |
? | |
methane + duroquinol + O2 | Methylococcus capsulatus Bath | - |
methanol + duroquinone + H2O | - |
? | |
methane + duroquinol + O2 | Methylomicrobium album BG8 | - |
methanol + duroquinone + H2O | - |
? | |
methane + reduced acceptor + H* + O2 | Methylococcus capsulatus | - |
methanol + acceptor + H2O | - |
? | |
methane + reduced acceptor + H* + O2 | Methylomicrobium album | - |
methanol + acceptor + H2O | - |
? | |
methane + reduced acceptor + H* + O2 | Methylocystis sp. | - |
methanol + acceptor + H2O | - |
? | |
methane + reduced acceptor + H* + O2 | Methylococcus capsulatus Bath | - |
methanol + acceptor + H2O | - |
? | |
methane + reduced acceptor + H* + O2 | Methylomicrobium album BG8 | - |
methanol + acceptor + H2O | - |
? | |
additional information | Methylococcus capsulatus | the sMMO enzyme has broad substrate specificity compared to pMMO | ? | - |
? | |
additional information | Methylomicrobium album | the sMMO enzyme has broad substrate specificity compared to pMMO | ? | - |
? | |
additional information | Methylocystis sp. | the sMMO enzyme has broad substrate specificity compared to pMMO | ? | - |
? | |
additional information | Methylococcus capsulatus Bath | the sMMO enzyme has broad substrate specificity compared to pMMO | ? | - |
? | |
additional information | Methylomicrobium album BG8 | the sMMO enzyme has broad substrate specificity compared to pMMO | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methylococcus capsulatus | - |
- |
- |
Methylococcus capsulatus Bath | - |
- |
- |
Methylocystis sp. | - |
- |
- |
Methylomicrobium album | - |
- |
- |
Methylomicrobium album BG8 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
methane + duroquinol + O2 | - |
Methylococcus capsulatus | methanol + duroquinone + H2O | - |
? | |
methane + duroquinol + O2 | - |
Methylomicrobium album | methanol + duroquinone + H2O | - |
? | |
methane + duroquinol + O2 | - |
Methylocystis sp. | methanol + duroquinone + H2O | - |
? | |
methane + duroquinol + O2 | - |
Methylococcus capsulatus Bath | methanol + duroquinone + H2O | - |
? | |
methane + duroquinol + O2 | - |
Methylomicrobium album BG8 | methanol + duroquinone + H2O | - |
? | |
methane + reduced acceptor + H* + O2 | - |
Methylococcus capsulatus | methanol + acceptor + H2O | - |
? | |
methane + reduced acceptor + H* + O2 | - |
Methylomicrobium album | methanol + acceptor + H2O | - |
? | |
methane + reduced acceptor + H* + O2 | - |
Methylocystis sp. | methanol + acceptor + H2O | - |
? | |
methane + reduced acceptor + H* + O2 | - |
Methylococcus capsulatus Bath | methanol + acceptor + H2O | - |
? | |
methane + reduced acceptor + H* + O2 | - |
Methylomicrobium album BG8 | methanol + acceptor + H2O | - |
? | |
additional information | the sMMO enzyme has broad substrate specificity compared to pMMO | Methylococcus capsulatus | ? | - |
? | |
additional information | the sMMO enzyme has broad substrate specificity compared to pMMO | Methylomicrobium album | ? | - |
? | |
additional information | the sMMO enzyme has broad substrate specificity compared to pMMO | Methylocystis sp. | ? | - |
? | |
additional information | the sMMO enzyme has broad substrate specificity compared to pMMO | Methylococcus capsulatus Bath | ? | - |
? | |
additional information | the sMMO enzyme has broad substrate specificity compared to pMMO | Methylomicrobium album BG8 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sMMO | - |
Methylococcus capsulatus |
sMMO | - |
Methylomicrobium album |
sMMO | - |
Methylocystis sp. |
soluble methane monooxygenase | - |
Methylococcus capsulatus |
soluble methane monooxygenase | - |
Methylomicrobium album |
soluble methane monooxygenase | - |
Methylocystis sp. |
Organism | Comment | Expression |
---|---|---|
Methylococcus capsulatus | transcription of sMMO is arrested in cells exposed to high levels of copper ions and sMMO mRNA transcripts are not detected 15 min after the addition of CuSO4 | down |
Methylomicrobium album | transcription of sMMO is arrested in cells exposed to high levels of copper ions and sMMO mRNA transcripts are not detected 15 min after the addition of CuSO4 | down |
Methylocystis sp. | transcription of sMMO is arrested in cells exposed to high levels of copper ions and sMMO mRNA transcripts are not detected 15 min after the addition of CuSO4 | down |
Methylococcus capsulatus | the sMMO enzyme is expressed when cells are essentially starved for copper and the copper-to-biomass ratio is low (less than 0.0002 mM Cu2+) | up |
Methylomicrobium album | the sMMO enzyme is expressed when cells are essentially starved for copper and the copper-to-biomass ratio is low (less than 0.0002 mM Cu2+) | up |
Methylocystis sp. | the sMMO enzyme is expressed when cells are essentially starved for copper and the copper-to-biomass ratio is low (less than 0.0002 mM Cu2+) | up |