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Literature summary for 1.14.13.39 extracted from

  • Panda, K.; Adak, S.; Konas, D.; Sharma, M.; Stuehr, D.J.
    A conserved aspartate (Asp-1393) regulates NADPH reduction of neuronal nitric-oxide synthase: implications for catalysis (2004), J. Biol. Chem., 279, 18323-18333.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
D1393E normal composition, spectral properties and binding of cofactors, substrates and calmodulin, slower NADPH-dependent cytochrome c and ferricyanide reductase activity Rattus norvegicus
D1393N normal composition, spectral properties and binding of cofactors, substrates and calmodulin, slower NADPH-dependent cytochrome c and ferricyanide reductase activity Rattus norvegicus
D1393V normal composition, spectral properties and binding of cofactors, substrates and calmodulin, slower NADPH-dependent cytochrome c and ferricyanide reductase activity Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
NADPH mutant D1393E Rattus norvegicus
0.0013
-
NADPH mutant D1393N Rattus norvegicus
0.0025
-
NADPH wild-type Rattus norvegicus
0.0029
-
NADPH mutant D1393V Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Iron heme Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
flavoprotein
-
Rattus norvegicus
additional information hemoprotein Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-hydroxy-L-arginine + NADPH + O2
-
Rattus norvegicus ? + NO + NADP+
-
?

Cofactor

Cofactor Comment Organism Structure
5,6,7,8-tetrahydro-L-biopterin
-
Rattus norvegicus
NADPH
-
Rattus norvegicus