Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P29474 | - |
- |
Homo sapiens | P29475 | - |
- |
Homo sapiens | P35228 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
nitric oxide synthase | - |
Homo sapiens |
NO synthase type I | nNOS | Homo sapiens |
NO synthase type II | iNOS | Homo sapiens |
NO synthase type III | eNOS | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression of eNOS mRNA and protein does not change in mild to moderate chronic obstructive pulmonary disease, but is reduced in the more severe stages of chronic obstructive pulmonary disease | down |
Homo sapiens | in the peripheral lung of chronic obstructive pulmonary disease patients iNOS mRNA expression is increased at earlier stages of the disease but decreases in the most severe patients, pro-inflammatory cytokine-induced iNOS expression is decreased by oxidative stress, such as H2O2, cigarette smoke conditioned media, and the peroxyntrite generator SIN1 | up |
Homo sapiens | lung tissue from patients with severe and very severe chronic obstructive pulmonary disease have graded increases in nNOS (mRNA and protein) compared with non-smokers and normal smokers | up |