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Literature summary for 1.14.13.39 extracted from

  • Schmidt, A.; Bilgasem, S.; Lorkowski, S.; Vischer, P.; Voelker, W.; Breithardt, G.; Siegel, G.; Buddecke, E.
    Exogenous nitric oxide regulates activity and synthesis of vascular endothelial nitric oxide synthase (2008), Eur. J. Clin. Invest., 38, 476-485.
    View publication on PubMed
Search for more literature for 1.14.13.39

Activating Compound

Activating Compound Comment Organism Structure
additional information short-term (20-30 min) treatment of endothelial cells with the synthetic NO donor (Z)-1-[2-(2-aminoethyl)-N-(2-aminoethyl)amino](diazen-1-ium-1,2-diolate) increases the Ser1177 phosphorylation of the constitutively expressed endothelial NOS and the production of endogenous NO generated by eNOS from L-arginine, the phosphorylation of eNOS is Akt-dependent and completely reverted by the phosphatidylinositol-3 kinase inhibitor LY-294002 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-nitro-L-arginine methyl ester competitive NOS inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Homo sapiens
-
HUVEC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2
-
 Homo sapiens 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
-
 ?

Synonyms

Synonyms Comment Organism
endothelial nitric oxide synthase
-
 Homo sapiens
endothelial NO synthase
-
 Homo sapiens
eNOS
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
5,6,7,8-tetrahydro-L-biopterin
-
 Homo sapiens
Calmodulin
-
 Homo sapiens
NADPH
-
 Homo sapiens