Activating Compound | Comment | Organism | Structure |
---|---|---|---|
thyroxin | 0.001 mg thyroxin significantly increases nNOS activity and nNOS protein level to 153% compared to control | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-n-propyl-2-thyouracil | 0.1 mg 6-n-propyl-2-thyouracil decreases nNOS activity to 45% compared to control | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P29476 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebral cortex | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 | - |
Rattus norvegicus | 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neuronal nitric oxide synthase | - |
Rattus norvegicus |
nNOS | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5,6,7,8-tetrahydro-L-biopterin | - |
Rattus norvegicus | |
Calmodulin | - |
Rattus norvegicus | |
NADPH | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | 0.1 mg 6-n-propyl-2-thyouracil decreases nNOS protein level to 19% compared to control | down |
Rattus norvegicus | 0.001 mg thyroxin significantly increases nNOS protein level to 178% compared to control | up |