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Literature summary for 1.14.13.64 extracted from

  • Moonen, M.J.H.; Fraaije, M.W.; Rietjens, I.M.C.M.; Laane, C.; Van Berkel, W.J.H.
    Flavoenzyme-catalyzed oxygenations and oxidations of phenolic compounds (2002), Adv. Synth. Catal., 344, 1023-1035.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
3,5-Dichloro-4-hydroxybenzoate
-
Candida parapsilosis
4-Hydroxy-3,5-dinitrobenzoate
-
Candida parapsilosis
4-Hydroxyisophthalate
-
Candida parapsilosis
Cl-
-
Candida parapsilosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
-
Candida parapsilosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Candida parapsilosis the enzyme is induced when yeast is grown on either 4-hydroxybenzoate, 2,4-dihydroxybenzoate or 3,4-dihydroxybenzoate as the sole carbon source ?
-
?
additional information Candida parapsilosis CBS604 the enzyme is induced when yeast is grown on either 4-hydroxybenzoate, 2,4-dihydroxybenzoate or 3,4-dihydroxybenzoate as the sole carbon source ?
-
?

Organism

Organism UniProt Comment Textmining
Candida parapsilosis
-
CBS604
-
Candida parapsilosis CBS604
-
CBS604
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxy-3-nitrobenzoate + NAD(P)H + O2
-
Candida parapsilosis 2-nitrobenzene-1,4-diol + NAD(P)+ + CO2
-
?
4-hydroxy-3-nitrobenzoate + NAD(P)H + O2
-
Candida parapsilosis CBS604 2-nitrobenzene-1,4-diol + NAD(P)+ + CO2
-
?
4-hydroxybenzoate + NADH + O2 the enzyme prefers NADH over NADPH as electron donor Candida parapsilosis hydroquinone + NAD+ + CO2
-
?
4-hydroxybenzoate + NADH + O2 the enzyme prefers NADH over NADPH as electron donor Candida parapsilosis CBS604 hydroquinone + NAD+ + CO2
-
?
4-hydroxybenzoate + NADPH + O2 the enzyme prefers NADH over NADPH as electron donor Candida parapsilosis hydroquinone + NADP+ + CO2
-
?
4-hydroxybenzoate + NADPH + O2 the enzyme prefers NADH over NADPH as electron donor Candida parapsilosis CBS604 hydroquinone + NADP+ + CO2
-
?
additional information the enzyme is induced when yeast is grown on either 4-hydroxybenzoate, 2,4-dihydroxybenzoate or 3,4-dihydroxybenzoate as the sole carbon source Candida parapsilosis ?
-
?
additional information the phenolate form of the substrates is important for catalysis and the substrate hydroxylation involvesthe electrophilic attack of the putative flavin hydroperoxide at the C1-atom of the aromatic ring Candida parapsilosis ?
-
?
additional information the enzyme is induced when yeast is grown on either 4-hydroxybenzoate, 2,4-dihydroxybenzoate or 3,4-dihydroxybenzoate as the sole carbon source Candida parapsilosis CBS604 ?
-
?
additional information the phenolate form of the substrates is important for catalysis and the substrate hydroxylation involvesthe electrophilic attack of the putative flavin hydroperoxide at the C1-atom of the aromatic ring Candida parapsilosis CBS604 ?
-
?
tetrafluoro-4-hydroxybenzoate + NAD(P)H + O2
-
Candida parapsilosis 2,3,5,6-tetrafluorohydroquinone + NAD(P)+ + CO2
-
?

Subunits

Subunits Comment Organism
monomer 1 * 50000 Candida parapsilosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Candida parapsilosis

Cofactor

Cofactor Comment Organism Structure
FAD dependent on Candida parapsilosis
NADH the enzyme prefers NADH over NADPH as electron donor Candida parapsilosis
NADPH the enzyme prefers NADH over NADPH as electron donor Candida parapsilosis