Application | Comment | Organism |
---|---|---|
medicine | enzyme is a therapeutical target for treatment of Huntigton disease | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide | i.e. Ro 61-8048, high-affinity low molecular inhibitor | Saccharomyces cerevisiae | |
Ro 61-8048 | high-affinity low molecular inhibitor | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + NADPH + O2 | Homo sapiens | step in L-tryptophan catabolism, overview | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
L-kynurenine + NADPH + O2 | Saccharomyces cerevisiae | step in L-tryptophan catabolism, overview | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
additional information | Homo sapiens | the enzyme is a very potent suppressor of toxicity of a fragment of the protein huntingtin, Htt, which causes the neurodegenerative Huntington disease by aggregation in nuclear and cytoplasmic inclusion bodies | ? | - |
? | |
additional information | Saccharomyces cerevisiae | the enzyme is a very potent suppressor of toxicity of a fragment of the protein huntingtin, Htt, which causes the neurodegenerative Huntington disease in humans by aggregation in nuclear and cytoplasmic inclusion bodies | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | - |
diverse strains | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-kynurenine + NADPH + O2 | - |
Homo sapiens | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
L-kynurenine + NADPH + O2 | - |
Saccharomyces cerevisiae | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
L-kynurenine + NADPH + O2 | step in L-tryptophan catabolism, overview | Homo sapiens | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
L-kynurenine + NADPH + O2 | step in L-tryptophan catabolism, overview | Saccharomyces cerevisiae | 3-hydroxy-L-kynurenine + NADP+ + H2O | - |
? | |
additional information | the enzyme is a very potent suppressor of toxicity of a fragment of the protein huntingtin, Htt, which causes the neurodegenerative Huntington disease by aggregation in nuclear and cytoplasmic inclusion bodies | Homo sapiens | ? | - |
? | |
additional information | the enzyme is a very potent suppressor of toxicity of a fragment of the protein huntingtin, Htt, which causes the neurodegenerative Huntington disease in humans by aggregation in nuclear and cytoplasmic inclusion bodies | Saccharomyces cerevisiae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Bna4 | - |
Homo sapiens |
Bna4 | - |
Saccharomyces cerevisiae |
KMO | - |
Homo sapiens |
KMO | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Saccharomyces cerevisiae |