Application | Comment | Organism |
---|---|---|
synthesis | production of 6-beta-hydroxy-methyl-simvastatin, simvastatin and derivatives belong to the family of HMG-CoA reductase inhibitors, which are potent cholesterol-lowering therapeutic agents | Pseudonocardia autotrophica |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudonocardia autotrophica | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
simvastatin + [reduced NADPH-hemoprotein reductase] + O2 | - |
Pseudonocardia autotrophica | 6-beta-hydroxy-methyl-simvastatin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
27 | - |
- |
Pseudonocardia autotrophica |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
- |
Pseudonocardia autotrophica |