Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is induced and inhibited by the fungicide bitertanol, application increases the activiy of several cytochrome P450 monooxygenases in liver, kidney, and lung several fold, overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bitertanol | 7-ethoxyresorufin O-deethylation is inhibited by the fungicide bitertanol, IC50: 800-900 nM | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-ethoxyresorufin + O2 + reduced donor | 7-ethoxyresorufin O-deethylation | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP1A1 | - |
Rattus norvegicus |
CYP1B1 | - |
Rattus norvegicus |
CYP2B | - |
Rattus norvegicus |
CYP3A | - |
Rattus norvegicus |
cytochrome P450-dependent monooxygenase | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0008 | 0.0009 | 7-ethoxyresorufin O-deethylation is inhibited by the fungicide bitertanol, IC50: 800-900 nM | Rattus norvegicus | bitertanol |