Cloned (Comment) | Organism |
---|---|
V79-hCYP2E1 (constructed by transfection of CYP2E1-expressing vector pSV together with vector pSV2neo containing a G418-selective marker into V79-Mz cells) and SULT1A1 expression vector introduced into this cell line | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-aminobenzotriazole | moderately prohibits spontaneous mutations of V79-hCYP2E1-hSULT1A1 cells. In combination with SULT1A1 inhibitor pentachlorophenol completely prohibits spontaneous mutations of V79-hCYP2E1-hSULT1A1 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
chlorzoxazone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP2E1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | V79-hCYP2E1-hSULT1A1 cells contain a higher level of hCYP2E1 protein than the parental V79-hCYP2E1 line (by a factor of 34) | up |
General Information | Comment | Organism |
---|---|---|
physiological function | CYP2E1 and sulfotransferase SULT1A1 activate an endogenous cellular molecule or a medium component to become mutagenic | Homo sapiens |