Application | Comment | Organism |
---|---|---|
medicine | during degradation of permethrins, potential dispositional differences may occur with permethrin enantiomers. Cleavage of pyrethroid esters leads to detoxification of the acute neurological effects, but formation of the benzyl alcohol and hydroxylated metabolite may lead to estrogenic responses | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ketoconazole | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.055 | - |
(1R)-cis-permethrin | product 3-(4'-hydroxyphenoxy)-benzyl alcohol, pH 7.4,37°C | Homo sapiens | |
0.057 | - |
(1S)-cis-permethrin | product 3-(4'-hydroxyphenoxy)-benzyl alcohol, pH 7.4,37°C | Homo sapiens | |
0.061 | - |
(1R)-cis-permethrin | product 3-phenoxybenzyl alcohol, pH 7.4,37°C | Homo sapiens | |
0.063 | - |
(1S)-cis-permethrin | product 3-phenoxybenzyl alcohol, pH 7.4,37°C | Homo sapiens | |
0.101 | - |
(1S)-trans-permethrin | product 3-phenoxybenzyl alcohol, pH 7.4,37°C | Homo sapiens | |
0.106 | - |
(1S)-trans-permethrin | product 3-(4'-hydroxyphenoxy)-benzyl alcohol, pH 7.4,37°C | Homo sapiens | |
0.115 | - |
(1R)-trans-permethrin | product 3-(4'-hydroxyphenoxy)-benzyl alcohol, pH 7.4,37°C | Homo sapiens | |
0.131 | - |
(1R)-trans-permethrin | product 3-phenoxybenzyl alcohol, pH 7.4,37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(1R)-cis-permethrin + O2 + [reduced NADPH-hemoprotein reductase] | - |
Homo sapiens | 3-phenoxybenzyl alcohol + 3-(4'-hydroxyphenoxy)-benzyl alcohol + [oxidized NADPH-hemoprotein reductase] | - |
? | |
(1R)-trans-permethrin + O2 + [reduced NADPH-hemoprotein reductase] | - |
Homo sapiens | 3-phenoxybenzyl alcohol + 3-(4'-hydroxyphenoxy)-benzyl alcohol + [oxidized NADPH-hemoprotein reductase] | - |
? | |
(1S)-cis-permethrin + O2 + [reduced NADPH-hemoprotein reductase] | - |
Homo sapiens | 3-phenoxybenzyl alcohol + 3-(4'-hydroxyphenoxy)-benzyl alcohol + [oxidized NADPH-hemoprotein reductase] | - |
? | |
(1S)-trans-permethrin + O2 + [reduced NADPH-hemoprotein reductase] | - |
Homo sapiens | 3-phenoxybenzyl alcohol + 3-(4'-hydroxyphenoxy)-benzyl alcohol + [oxidized NADPH-hemoprotein reductase] | - |
? | |
additional information | (1R)-trans-permethrin is the best substrate among the permethrin enantiomers | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP3A4 | - |
Homo sapiens |