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Literature summary for 1.14.14.1 extracted from
- An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase (2021), Commun. Biol., 4, 55 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P04798 | isoform CYP1A1 | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP1A1 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | upon binding NADPH-cytochrome P450 oxidoreductase CPR, the interaction between CYP1A1 and the membrane becomes weaker, as the CYP1A1-FMN domain interface area increases. The CYP1A1 catalytic domain reorients in the membrane. This reorientation affects ligand access and egress pathways between the active site and the membrane. CPR rearranges in the membrane and undergoes a large conformational change from the open to the semi-open form, which enables the formation of an additional interface between the distal side of CYP1A1 and the CPR NADP domain | Homo sapiens |
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