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Literature summary for 1.14.14.13 extracted from
- Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway (2005), Chem. Biol., 12, 665-675.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Niallia circulans |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 38700 | - |
x * 38700, calculated, x * 40000, SDS-PAGE of recombinant His-tagged protein | Niallia circulans |
| 40000 | - |
x * 38700, calculated, x * 40000, SDS-PAGE of recombinant His-tagged protein | Niallia circulans |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Niallia circulans | Q4H4E5 | putative | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-(L-gamma-glutamylamino)butanoyl-[BtrI acyl-carrier protein] + FMNH2 + O2 | presence of FMN and O2 are required | Niallia circulans | 4-(L-gamma-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + FMN + H2O | - |
? |  |
| butanoyl-[BtrI acyl-carrier protein] + FMNH2 + O2 | - |
Niallia circulans | (2S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + FMN + H2O | - |
? | |
| additional information | no substrates: butanoate, butanoyl-CoA, L-glutamate, L-aspartate, gamma-aminobutanoate, and L-ornithine | Niallia circulans | ? | - |
? | |
| octanoyl-[BtrI acyl-carrier protein] + FMNH2 + O2 | - |
Niallia circulans | (2S)-2-hydroxyoctanoyl-[BtrI acyl-carrier protein] + FMN + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 38700, calculated, x * 40000, SDS-PAGE of recombinant His-tagged protein | Niallia circulans |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| btrO | - |
Niallia circulans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FMN | - |
Niallia circulans | |
| additional information | no cofactor: FAD | Niallia circulans |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | involved in biosynthesis of the aminoglycoside antibiotic butirosin | Niallia circulans |
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Release 2023.1 (January 2023)
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