Inhibitors | Comment | Organism | Structure |
---|---|---|---|
19-hydroxyandrost-4-ene-3,17-dione | competitively inhibits the formation of 19-hydroxyandrost-4-ene-3,17-dione and estrogen | Homo sapiens | |
19-oxoandrost-4-ene-3,17-dione | competitively inhibits the formation of 19-oxoandrost-4-ene-3,17-dione and estrogen | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
19-hydroxyandrost-4-ene-3,17-dione + O2 + a reduced flavoprotein | - |
Homo sapiens | 19-oxo-androst-4-ene-3,17-dione + 2 H2O + an oxidized flavoprotein | - |
? | |
19-oxoandrost-4-ene-3,17-dione + O2 + a reduced flavoprotein | - |
Homo sapiens | estrone + formate + H2O + an oxidized flavoprotein | - |
? | |
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins | - |
Homo sapiens | estrone + formate + 4 H2O + 3 oxidized flavoproteins | overall reaction | ? | |
androst-4-ene-3,17-dione + O2 + a reduced flavoprotein | - |
Homo sapiens | 19-hydroxyandrost-4-ene-3,17-dione + H2O + an oxidized flavoprotein | - |
? | |
additional information | the aromatization of androstenedione probably involves two successive hydroxylations at the C-19 methyl group, mediated by a common catalytic site with the third and rate-determining 2beta-hydroxylation taking place at a different enzyme site | Homo sapiens | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00038 | - |
19-hydroxyandrost-4-ene-3,17-dione | substrate 19-oxoandrost-4-ene-3,17-dione, pH 7.0, 37°C | Homo sapiens | |
0.00045 | - |
19-hydroxyandrost-4-ene-3,17-dione | substrate androst-4-ene-3,17-dione, pH 7.0, 37°C | Homo sapiens | |
0.0015 | - |
19-oxoandrost-4-ene-3,17-dione | substrate 19-hydroxyandrost-4-ene-3,17-dione, pH 7.0, 37°C | Homo sapiens | |
0.003 | - |
19-oxoandrost-4-ene-3,17-dione | substrate androst-4-ene-3,17-dione, pH 7.0, 37°C | Homo sapiens |