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Literature summary for 1.14.14.16 extracted from

  • Kishimoto, W.; Hiroi, T.; Shiraishi, M.; Osada, M.; Imaoka, S.; Kominami, S.; Igarashi, T.; Funae, Y.
    Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain (2004), Endocrinology, 145, 699-705.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
fluoxetine 50% inhibition at 0.002 mM, substrate allopregnanolone Rattus norvegicus
quinidine
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome microsomal steroid 21-hydroxylation is not catalyzed by P450c21, but by CYP2D isoforms Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17-hydroxy-progesterone + NADH + O2 isozyme CYP2D Rattus norvegicus 17-hydroxy-11-deoxy-corticosterone + NAD+ + H2O
-
?
allopregnanolone + NADH + O2 isozyme CYP2D4, CYP2D6 Rattus norvegicus 21-hydroxy-allopregnanolone + NAD+ + H2O
-
?
progesterone + NADH + O2 isozyme CYP2D Rattus norvegicus deoxycorticosterone + NAD+ + H2O
-
?

Synonyms

Synonyms Comment Organism
CYP2D
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Rattus norvegicus