Cloned (Comment) | Organism |
---|---|
gene sq1-1 encoding isozyme SQ1, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in enzyme-deficient Saccharomyces cerevisiae strain RXY6.2 | Arabidopsis thaliana |
gene sq1-2 encoding isozyme SQ2, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in enzyme-deficient Saccharomyces cerevisiae strain RXY6.2 | Arabidopsis thaliana |
gene sq1-4 encoding isozyme SQ4, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in enzyme-deficient Saccharomyces cerevisiae strain RXY6.2 | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of mutant transgenic plants with defective isozyme SQ1 using the Agrobacterium tumefaciens GV3101 transfection method, sqe1 mutants show severe developmental defects, including reduced root and hypocotyl elongation, adult sqe1-3 and sqe1-4 plants have diminished stature and produce inviable seeds, the sqe1-3 mutant accumulates squalene, consistent with a block in the triterpenoid biosynthetic pathway, phenotypes, overview | Arabidopsis thaliana |
additional information | construction of mutant transgenic plants with defective isozyme SQ2 using the Agrobacterium tumefaciens GV3101 transfection method, sqe1 mutants show severe developmental defects, including reduced root and hypocotyl elongation, adult sqe1-3 and sqe1-4 plants have diminished stature and produce inviable seeds, the sqe1-3 mutant accumulates squalene, consistent with a block in the triterpenoid biosynthetic pathway, phenotype, overview | Arabidopsis thaliana |
additional information | construction of mutant transgenic plants with defective isozyme SQ3 using the Agrobacterium tumefaciens GV3101 transfection method, sqe1 mutants show severe developmental defects, including reduced root and hypocotyl elongation, adult sqe1-3 and sqe1-4 plants have diminished stature and produce inviable seeds, the sqe1-3 mutant accumulates squalene, consistent with a block in the triterpenoid biosynthetic pathway. Homozygous sqe1-3 plants are completely infertile whether grown in soil or hydroponically. eed pods of sqe1-3 plants grown hydroponically elongated nearly normally, but sqe1-3 siliques are slightly thinner than wild type and contained shriveled, inviable seeds, phenotypes, overview | Arabidopsis thaliana |
additional information | construction of mutant transgenic plants with defective isozyme SQ4 using the Agrobacterium tumefaciens GV3101 transfection method, sqe1 mutants show severe developmental defects, including reduced root and hypocotyl elongation, adult sqe1-3 and sqe1-4 plants have diminished stature and produce inviable seeds, the sqe1-3 mutant accumulates squalene, consistent with a block in the triterpenoid biosynthetic pathway, phenotypes, overview | Arabidopsis thaliana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Arabidopsis thaliana | Arabidopsis thaliana squalene epoxidase 1 is essential for root and seed development | ? | - |
? | |
squalene + AH2 + O2 | Arabidopsis thaliana | production of the precursor for all known angiosperm cyclic triterpenoids, which include membrane sterols, brassinosteroid phytohormones, and non-steroidal triterpenoids, overview | (S)-squalene-2,3-epoxide + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | O65403 | gene sq1-4, isozyme SQ4; isozymes SQE1-SQE6 | - |
Arabidopsis thaliana | O81000 | gene sq1-2, isozyme SQ2; isozymes SQE1-SQE6 | - |
Arabidopsis thaliana | Q8VYH2 | gene sq1-3, isozyme SQ3; isozymes SQE1-SQE6 | - |
Arabidopsis thaliana | Q9SM02 | gene sq1-1, isozyme SQ1; isozymes SQE1-SQE6 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
root | - |
Arabidopsis thaliana | - |
seed | developing | Arabidopsis thaliana | - |
seedling | - |
Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Arabidopsis thaliana squalene epoxidase 1 is essential for root and seed development | Arabidopsis thaliana | ? | - |
? | |
squalene + AH2 + O2 | - |
Arabidopsis thaliana | (S)-squalene-2,3-epoxide + A + H2O | - |
? | |
squalene + AH2 + O2 | production of the precursor for all known angiosperm cyclic triterpenoids, which include membrane sterols, brassinosteroid phytohormones, and non-steroidal triterpenoids, overview | Arabidopsis thaliana | (S)-squalene-2,3-epoxide + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
squalene epoxidase 1 | - |
Arabidopsis thaliana |