Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2,4,6-Trinitrobenzene sulfonic acid | induces HO-1 expression in the colon and stimulates its catalytic activity | Rattus norvegicus | |
5-aminosalicylic acid | induces HO-1 expression in the colon and stimulates its catalytic activity | Rattus norvegicus | |
additional information | HO-1 is a heat shock protein with anti-inflammatory activity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
zinc protoporphyrin | ZnPP, supresses enzyme induction and inhibits HO-1, it also abolishes the anti-colitic effect of 5-aminosalicylic acid | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | Rattus norvegicus | HO-1 is a heat shock protein, and it provides endogenous anti-oxidant and anti-inflammatory moieties which can modulate colonic inflammation | biliverdin + Fe2+ + CO + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P06762 | male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | - |
Rattus norvegicus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | HO-1 is a heat shock protein, and it provides endogenous anti-oxidant and anti-inflammatory moieties which can modulate colonic inflammation | Rattus norvegicus | biliverdin + Fe2+ + CO + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Rattus norvegicus |
HO-1 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |